Results from comparative animal experimental study on the effects of its candidate substance Libiguin® DIC2024 versus the active substance in Viagra®

Press release: Uppsala, August 26, 2019. Dicot AB (publ), developer of drugs targeting sexual dysfunctions, today announced that the company has conducted a comparative animal experimental study on the effects of its candidate substance Libiguin® DIC2024 versus the active substance in Viagra®, namely sildenafil, the latter which belongs to the substance group PDE-5 inhibitors used for treatment of erectile dysfunction.

The compounds were administered to male rats, which were then introduced to female rats, who had been made sexually receptive by treatment with sex hormones (estrogen and progesterone). Both, DIC2024 and sildenafil, significantly stimulated the mating behavior, however, the behavioral patterns induced differed noticeably, which indicates that the mechanisms of action of the two compounds differ markedly.

Sildenafil shortened the time from the initial dosing to when the male rats mounted the female rats and penetrated vaginally, without particularly affecting other measured parameters. Libiguin® DIC2024 significantly increased the number of mounts and vaginal penetrations, while simultaneously shortening the time from the initial dosing to when the male rats mounted and penetrated the female rats. Additionally, these trials reproduced results that Libiguin® DIC2024, unlike sildenafil, has a long-lasting effect: after an initial treatment for three days, the effects of DIC2024 persists for between 7-14 days after the treatment.

"The trials show clear differences in the effect profiles for DIC2024 and a PDE-5 inhibitor", says Dicot"s CEO Göran Beijer,"The results from the behavioral studies can be interpreted so that DIC2024 stimulates both desire, as evidenced by the increased number of mounts and penetrations by the male rats, and the ability, as evidenced by the shortened time from the initial dosing to when the male rats. Thus, the results indicate that Libiguin® DIC2024 has its very own effect profile with the potential to treat sexual dysfunctions, and is not just a variant of the currently used PDE-5 inhibitory drugs. In future clinical studies, our hope is to show how Libiguin® DIC2024 can thereby be used to treat sexual dysfunctions in an improved way compared to current treatments."

Footnote: Viagra® is a registered trademark of Pfizer Inc., USA.

For more information, please contact:

Julie Silber

CFO/Investor Relations Director, Dicot

Tel.: +46-79-3486277

Email: [email protected]

About Dicot AB (publ)

Dicot"s business concept is to develop the product LibiguinTM as a drug for the treatment of sexual dysfunctions. The development takes place in-house up to clinical phases. It is the company"s intention to subsequently enter into strategic alliances at appropriate times, or alternatively conduct a trade sale, with established major pharmaceutical companies to be able to introduce LibiguinTM on the world market. Dicot is listed on the Spotlight Stock Market and has approximately 700 shareholders. www.dicot.se

This information is such that Dicot AB is required to make public in accordance with the EU's Market Abuse Regulation (MAR). The information was made public by the Company's contact person above on August 26, 2019.

Nerladdningsbara filer

Dicot uppvisar goda resultat i ny effektstudie

Pressmeddelande: Uppsala, 29 juni 2022. Dicot AB utvecklar ett nytt potensläkemedel med målsättningen att bli förstahandsvalet på marknaden. Bolaget meddelar idag att den nyutvecklade orala formuleringen uppvisar goda resultat i en nyligen genomförd effektstudie.


Dicot demonstrates good results in new efficacy study

Press release: Uppsala, June 29, 2022. Dicot AB is developing a new potency drug aiming at becoming the first choice of treatment. The company announces today that the newly developed oral formulation demonstrates good results in a recently conducted efficacy study.


Dicot tillförs 10 MSEK genom utnyttjande av teckningsoptioner av serie TO 3 till 90% teckningsgrad

Pressmeddelande: Uppsala, 17 juni 2022.

Dicot AB (publ) ("Dicot" eller "Bolaget") meddelar utfallet från utnyttjandet av teckningsoptioner av serie TO 3. Innehavare av teckningsoptioner utnyttjade 34 202 814 teckningsoptioner, motsvarande cirka 90 procent av antalet utestående teckningsoptioner, för teckning av 34 202 814 aktier till teckningskursen 0,29 SEK per aktie. Genom utnyttjandet av teckningsoptionerna tillförs Dicot cirka 10 MSEK före emissionskostnader.


Dicot AB receives approximately 10 MSEK through the warrants of series TO 3 with a 90% subscription rate

Press release: Uppsala, June 17, 2022.

Dicot AB (publ) ("Dicot" or the "Company") announces the outcome regarding exercising of warrants of series TO 3. Holders of warrants exercised 34,202,814 warrants, corresponding to approximately 90 percent of the number of outstanding warrants, for subscription of 34,202,814 shares at a subscription price of SEK 0.29 per share. Through the exercise of the warrants, Dicot will receive approximately SEK 10 million before issue costs.


Medlemmar i Dicots styrelse och ledning stärker aktieinnehavet

Pressmeddelande: Uppsala, 13 juni 2022. Bolaget meddelar idag att medlemmar i Dicots styrelse och ledning ökar sitt aktieinnehav i bolaget.


Members of Dicot's board and management strengthen their shareholding

Press release: Uppsala, June 13, 2022. The company announces that members in the board and management are increasing their shareholding in the company.


Sista dag för handel med teckningsoptioner av serie TO 3 i Dicot

Den 13 juni 2022 är den sista dagen för handel med teckningsoptioner av serie TO 3 i Dicot AB (publ) ("Dicot" eller "Bolaget"). Utnyttjandeperioden för teckningsoptionerna av serie TO 3 pågår till och med den 15 juni 2022.


Last day of trading with the warrants of series TO 3 in Dicot

Today, June 13, 2022, is the last day of trading with the warrants of series TO 3. The subscription period for the warrants of series TO 3 will continue up until June 15, 2022.


Dicot går vidare med ny patentansökan

Pressmeddelande: Uppsala, 10 juni 2022. Dicot AB utvecklar läkemedelskandidaten LIB-01, ett potensläkemedel för att bättre behandla erektil dysfunktion och tidig utlösning. Bolaget meddelar att man nu går vidare med en ny patentansökan för att förlänga patentskyddet runt bolagets läkemedelskandidat till minst 2042.


Dicot moves forward with a new patent application

Press release: Uppsala, June 10, 2022. Dicot AB is developing the drug candidate LIB-01, a potency drug to better treat erectile dysfunction and premature ejaculation. The company announces that it is now moving forward with a new patent application in order to extend the patent protection around the company's drug candidate until at least 2042.


Dicot presenterar på Småbolagsdagarna måndag 13 juni

Uppsala, 9 juni 2022. Möt Dicots vd Elin Trampe på Småbolagsdagarna måndag 13 juni när hon presenterar bolagets utveckling av ett nytt potensläkemedel och de senaste framstegen. Hon kommer bland annat berätta om ett nystartat projekt med Uppsala universitet samt lyfta frågan om tystnadskulturen bland män med erektionsproblem.


Dicot presents at Småbolagsdagarna, Monday June 13

Uppsala, June 9, 2022. Meet Dicot's CEO Elin Trampe at Småbolagsdagarna on Monday June 13 when she presents the company's development of a new potency drug and the latest advances. Among other things, she will talk about a newly started project with Uppsala University and raise the issue of the culture of silence among men with erectile dysfunction.


Utnyttjandeperioden för teckningsoptioner av serie TO 3 i Dicot inleds idag

Idag, den 1 juni 2022, inleds utnyttjandeperioden för de teckningsoptioner av serie TO 3 som emitterades i samband med Dicot AB (publ) ("Dicot" eller "Bolaget") emission av units under det fjärde kvartalet 2021. Utnyttjandeperioden pågår till och med den 15 juni 2022.


The subscription period for warrants of series TO 3 in Dicot begins today

Today on June 1, 2022, the subscription period for the warrants of series TO 3 issued in connection with the rights issue of units in Dicot AB (publ) during the fourth quarter of 2021. The subscription period lasts until June 15, 2022.


Dicot AB går in i forskningssamarbete med Uppsala universitet och W. Szafer Institute of Botany

Uppsala, 31 maj 2022. Dicot AB utvecklar läkemedelskandidaten LIB-01, ett potensläkemedel för att bättre behandla erektil dysfunktion och tidig utlösning. Dicot meddelar idag att bolaget har inlett ett forskningssamarbete med Uppsala universitet och W. Szafer Institute of Botany vid Polska Vetenskapsakademin för att undersöka en ny teknik för framtagning av startmaterial för tillverkning av läkemedelssubstansen.


Dicot AB enters research collaboration with Uppsala University and the W. Szafer Institute of Botany

Uppsala, May 31, 2022. Dicot AB is developing the drug candidate LIB-01, which will be a potency agent to better treat erectile dysfunction and premature ejaculation. Dicot announces today that the company has entered a research collaboration with Uppsala University and the W. Szafer Institute of Botany of the Polish Academy of Sciences (PAS) to investigate a new technology to make starting material for production of the drug substance.


Teckningskursen för utnyttjandet av teckningsoptioner av serie TO 3 i Dicot har fastställts till 0,29 SEK per aktie

Pressmeddelande: Uppsala, 29 maj 2022.

Dicot AB (publ) ("Dicot" eller "Bolaget") genomförde under det fjärde kvartalet 2021 en företrädesemission av s.k. units vari en (1) unit bestod av tre (3) nyemitterade aktier och tre (3) vederlagsfria teckningsoptioner av serie TO 3 (även tidigare benämnd serie 2021/2022). De som tecknade units under teckningsperioden från och med den 12 oktober 2021 till och med den 27 oktober 2021 erhöll därmed tre (3) vidhängande vederlagsfria teckningsoptioner av serie TO 3 per tecknad unit i företrädesemissionen. Varje teckningsoption av serie TO 3 ger rätt att teckna en (1) ny aktie i Bolaget. Teckningskursen för teckningsoptionerna motsvarar 70 procent av den volymvägda genomsnittskursen i Bolagets aktie under perioden från och med den 16 maj 2022 till och med 27 maj 2022, dock inte lägre än aktiens kvotvärde (0,125 SEK) och inte högre än 1,50 SEK per aktie. Den genomsnittliga betalkursen uppgick under mätperioden till cirka 0,41 SEK och således är lösenpriset fastställt till 0,29 SEK per aktie.


The subscription price for the exercise of warrants of series TO 3 in Dicot AB has been set to 0.29 SEK per share

Press release: Uppsala, May 29, 2022.

During the fourth quarter of 2021, Dicot AB (publ) (``Dicot`` or ``the Company``) conducted a rights issue of units, with one (1) unit consisting of three (3) new issued shares and three (3) free-of-charge warrants of series TO 3 (previously also named series 2021/2022). Those who subscribed for units during the subscription period between October 12, 2021, and October 27, 2021, therefore obtained three (3) additional warrants of series TO 3 per unit subscribed. Each warrant of series TO 3 entitles the holder to subscribe for one (1) new share in Dicot. The subscription price for subscription of shares using warrants will correspond to 70 percent of the average volume-weighted price of the Company's share according to Spotlight Stock market's official list during the period from May 16, 2022, up to and including May 27, 2022. However, the subscription price shall not be higher than 1.50 SEK or lower than 0.125 SEK (corresponding quota value of the Company's share). The average volume-weighted price of the Company's share during the measurement period amounted to approximately 0.41 SEK, hence, the subscription price has been set to 0.29 SEK per share.


Kommuniké från årsstämma i Dicot AB

Dicot AB (publ) ("Bolaget") höll idag den 24 maj 2022 årsstämma i Uppsala varvid nedan beslut fattades.


Följ oss

Om beQuoted

beQuoted publicerar nyheter, analyser och pressmeddelanden för investerare och journalister. Viktiga företagshändelser bevakas av vår egen nyhetsredaktion och vidaredistribueras i ledande finansiella medier.

Vi uppdaterar även nyhetsrum, Investor Relations och IR-webbplatser för företag som vill utveckla sina relationer med finansmarknaden.

Kontakta oss

beQuoted AB
Nybrogatan 34
Box 5216
102 45 Stockholm

08-692 21 90

Om beQuoted