Cyxone step up activities and extend collaboration with global CRO around RA trial

Cyxone (publ) announces today that the company has signed a Letter of Agreement (LOA) with the internationally renowned clinical contract research organization (CRO) following on an early operations agreement (EOA) signed last month. The LOA is a key step for advancing the clinical phase 2b trial of Rabeximod in patients with rheumatoid arthritis

The agreement enables Cyxone to expand and intensify start-up activities for the phase 2b trial including site selections and regulatory submissions enabling an efficient route to enrolling patients into the trial within the shortest period of time.

Cyxone is developing Rabeximod, an oral potential second line treatment for patients suffering from the autoimmune disease rheumatoid arthritis (RA) and who do not respond to current standard of care treatments. This underserved patient population represents 25-40% of diagnosed patients. Based on previous preclinical and clinical results, the company is currently preparing for a phase 2b trial of Rabeximod in patients with RA. The trial will be double blind, randomized, placebo controlled consisting of three treatment arms comparing two different dose levels of Rabeximod on top standard treatment with methotrexate alone over a 16-week-treatment period with an 8-week extension and 2-week follow up.

"Following on an early clinical operations agreement which was signed in December, we quickly advance our collaboration with this Letter of Agreement; a signal of commitment from both parties. Cyxone has secured a partner with first-class rheumatoid arthritis trial expertise and a global network of research sites able to deliver efficiently and at the highest level of quality for the phase 2b trial," comments Tara Heitner, CEO, Cyxone.